Aging Research in Yeast (Subcellular Biochemistry)

Aging Research in Yeast (Subcellular Biochemistry) by Michael Breitenbach (Editor), S. Michal Jazwinski (Editor), Peter Laun (Editor)



This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

Review

From the reviews: “This book compiles some of the most exciting and promising research to date in the fields of anti-aging, longevity, and possibly even rejuvenation. The authors’ research examines the role of senescence in yeast and how it may relate to the chaotic autophagy of cancer cells. In sum, Aging Research will stir interest in both scientific and non-scientific arenas.” (The Electric Review, October, 2012)

From the Back Cover

This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

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Book Detail 

• Hardcover: 377 pages
• Publisher: Springer; 2012 edition (November 18, 2011)
• Language: English
• ISBN-10: 9400725604
• ISBN-13: 978-9400725607
• Product Dimensions: 9.8 x 6.4 x 0.9 inches
• Shipping Weight: 1.5 pounds

Handbook of Clinical Nutrition and Aging

Handbook of Clinical Nutrition and Aging (Nutrition and Health) by Connie W. Bales (Editor), Christine S. Ritchie (Editor).

As the older adult population continues to grow, so will the prevalence and incidence of age-related disorders. In Handbook of Clinical Nutrition and Aging, Second Edition, the editors and contributors (a panel of recognized academic nutritionists, geriatricians, clinicians and scientists) have thoroughly updated and revised their widely acclaimed first edition with fresh perspectives and the latest scientific and clinical developments in age-associated disease. New chapters tackle ecological perspectives on adult eating behavior, and behavioral theories applied to nutritional therapies in aging, while topics such as Sarcopenia and Cachexia are discussed in greater detail. The authors outline the physiological basis for each disorder, provide the latest information about the interaction of nutrition with these conditions, and review the potential routes and mechanisms for clinical intervention.

Timely and authoritative, Handbook of Clinical Nutrition and Aging, Second Edition is a unique, comprehensive resource and will prove a valuable guide to all nutritionists, physicians, nurses, dietitians, and speech-language and occupational therapists who provide care for the rapidly expanding aging population.

Handbook of Clinical Nutrition and Aging Review

"The editors, both highly respected in geriatric nutrition, have brought together legends in this field to produce an excellent handbook. This text excels in its thorough approach to important topics. Cutting-edge geriatric and nutrition sciences are infused with practical management concepts, making this text a valuable resource. Management is addressed thoroughly, going beyond traditional prescribed diets or a simplistic "supplements" approach. Misconceptions that are pervasive in nutritional and geriatric care are refreshingly corrected. The test is exceptionally well organized and rigorously referenced, and it includes a comprehensive index to facilitate use as a reference handbook." - Annals of Internal Medicine

"This book does a very credible job at reviewing what is known about nutrition in older persons. The handbook is a comprehensive and practical resource, offering practicing clinicians an up-to-date compendium of advice on appropriate nutritional therapies for older adults with chronic diseases and medical conditions. The material presented here is especially complete. Each chapter is well referenced and the book is thoroughly indexed. The Handbook of Clinical Nutrition and Aging should be in all health sciences libraries supporting geriatrics education and practice." -E-STREAMS

"This book does a good job at reviewing what is known about nutrition in older persons...a welcome addition." - Doody's Health Sciences book Review Journal
"This is the second edition of a comprehensive book that covers all nutritional aspects of older adults. … this new edition covers many new topics that have emerged over the past five years, making it timely and valuable. … The book is written for all healthcare professionals who work with older adults. … this is a very useful guide for all individuals involved in the care of the elderly. … The book is easy to navigate, with appropriate tables and charts throughout the chapters." (Amy Hess-Fischl, Doody’s Review Service, August, 2009)

“Handbook of Clinical Nutrition and Aging is a guide for physicians and other health care professionals who work with older adults, a high-risk population of rapidly increasing proportion. … The book is comprehensive, fully referenced, well organized, and practical and can be understood by all types of health professionals. … a well-written, comprehensive, user- friendly reference that physicians, dietitians, and other health professionals, including researchers working with older adults, will want to have on their bookshelves.” (Judy A. Driskell, Journal of the American Medical Association, January, 2011)

“This book covers the most relevant topics of nutrition in the old age … . primarily addresses experienced specialists in the field of geriatric medicine, particularly those with interest in nutritional aspects. Additionally, it is well suited for medical students, geriatricians in training, nutritionists, nurses, speech and occupational therapists … . This lapidary and well-written handbook comprises an excellent and up-to-date contribution which deserves to be recommended … for understanding the role of nutrition in the clinical aspects of nutritional management of older persons.” (Mirko Petrovic, Acta Clinica Belgica, Vol. 65 (4), 2010)

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Book Detail

• Hardcover: 673 pages
• Publisher: Humana Press; 2nd edition (April 28, 2009)
• Language: English
• ISBN-10: 1603273840
• ISBN-13: 978-1603273848
• Product Dimensions: 7 x 1.5 x 10 inches
• Shipping Weight: 3 pounds